A folate deficiency can lead to complications, especially in pregnant women. Hence, 400 μg of folic acid, 2 mg of vitamin B6, and 6 μg of vitamin B12 supplement regimen are followed. The RDI for folate is 400 mcg per day for most adults, 600 mcg per day during pregnancy, and 500 mcg per day while breastfeeding. Some evidence shows that folic acid supplements may mask vitamin-B12-induced megaloblastic anemia, which may cause an underlying vitamin B12 deficiency to go undetected (14, 15). Vitamin B12 Deficiency . Method Pharmaceuticals, LLC, Arlington, TX. Medically reviewed by Drugs.com. This is concerning because high levels of UMFA appear to be linked to various health concerns (1, 11, 12, 13, 14, 15, 16, 17). That said, they can interact with some prescription medications, including those used to treat seizures, rheumatoid arthritis, and parasitic infections. In contrast, a much smaller percentage of the folic acid you get from fortified foods or supplements gets turned into its active form in your gut (7). High folic acid intake may mask a vitamin B12 deficiency. shortness of breath. Folic acid and folate are two forms of vitamin B9. It helps make DNA and produce red blood cells. 8. Skin rash 2. Supplement dosages usually range from 400–800 mcg (1). Although folic acid is basically nontoxic in humans, some side effects have been reported. Folate, also known as vitamin B9, is a water-soluble vitamin that has many important functions in your body. Moreover, pregnant women or those planning to become pregnant often take them to reduce the risk of birth defects (1). 2. Bad taste in your mouth 2. The rest requires the help of your liver and other tissues to get converted via a slow and inefficient process (8). Folic acid’s role in cancer appears to be twofold. This damage is typically irreversible, which makes a delayed diagnosis of vitamin B12 deficiency particularly worrisome (18). Folic Acid and Pregnancy: How Much Do You Need. Furthermore, other research ties excessive use of folic acid supplements to mental decline (20). But a few studies still fail to establish the effect of this supplementation on high-risk individuals ( 7 ). That said, excess folic acid supplement intake may cause several side effects, including slower brain development in children and accelerated mental decline in older adults. [Ref], Decreased diphenylhydantoin serum levels were reported in patients taking 5 or 15 mg folic acid daily. Irritability 6. That said, excess folic acid supplement intake may cause several side effects, including slower brain development in children and accelerated mental decline in older adults. Taking doses of folic acid higher than 1mg can mask the symptoms of vitamin B12 deficiency, which can eventually damage the nervous system if it's not spotted and treated. According to WebMD, folic acid effects are these: While these are great to know, these are not the folic acid side effects I want to share with you. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur while taking folic acid: Rare. Folic acid, otherwise referred to as folate or B9, and vitamin D are two essential vitamins for good health. [Ref], Frequency not reported: Irritability, excitement, mental depression, confusion[Ref], 1. Find everything you need to know about folic acid (FA-8), including what it is used for, warnings, reviews, side effects, and interactions. Beans, oranges, asparagus, Brussels sprouts, avocados, and leafy greens all contain folate. Fever. You may report them to the FDA. For instance, research suggests that people previously diagnosed with prostate or colorectal cancer who supplemented with more than 1,000 mcg of folic acid per day have a 1.7–6.4% higher risk of the cancer recurring (33, 34). Nausea 3. This article discusses folic acid, its…, The B-complex vitamins include B1, B2, B3, B5, B6, B7, B9 and B12. Decreased vitamin B12 serum levels was reported with prolonged folic acid therapy. It’s found exclusively in vitamins and certain fortified foods. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Deficiency of folate is common, with studies suggesting prevalence of deficiencyas high as 85.5% as was shown in women between the ages of 16 and 49, living in the UK. Nonetheless, further research is necessary. Healthline Media does not provide medical advice, diagnosis, or treatment. Low blood levels of folate have been linked to health issues, such as a higher risk of birth defects, heart disease, stroke, and even certain cancers (2, 3, 4, 5, 6). This may be particularly detrimental to people with a history of cancer. We comply with the HONcode standard for trustworthy health information -, Vitamin/Mineral Supplementation and Deficiency. reddened skin. One study in healthy people over the age of 60 linked high folate levels to mental decline in those with low vitamin B12 levels — but not in those with normal B12 levels (15). "Product Information. Here are 4 potential side effects of too much folic acid. Our website services, content, and products are for informational purposes only. A deficiency in folic acid can cause many problems like increased bone marrow toxicity, nausea, abdominal pain, mouth ulcers, liver problems, fatigue, and a reduced red blood cell count. ferrous sulfate, folic acid, ergocalciferol, thiamine, Zinc, leucovorin, l-methylfolate, Deplin. But according to the Harvard School of Public Health, the message is simple: Taking vitamins and supplements can be an easy way for you to get your essential nutrients, especially the ones that are lacking in most foods. This article discusses folic acid, its benefits, sources, your risk of deficiency, and more. Your body uses folate and vitamin B12 very similarly, meaning that a deficiency in either can result in similar symptoms. Hardly anyone talks about folic acid side effects. Applies to folic acid: capsule, solution, tablet. It is also essential in energy production of cells, metabolism of proteins, synthesis of DNA as well as in the formation of normal red blood cells. 9 Signs and Symptoms of Vitamin B12 Deficiency. These side effects are usually mild and do not last long. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information are provided Another danger of excess folic acid intake is that it can mask a deficiency in vitamin B12, which can have detrimental effects on health if left untreated. In one study, 4- and 5-year-olds whose mothers supplemented with over 1,000 mcg of folic acid per day while pregnant — more than the Tolerable Upper Intake Level (UL) — scored lower on brain development tests than the children of women who took 400–999 mcg per day (16). As long as the daily dose remains under 1,000 mcg daily, side effects are unlikely to occur. Toxicity caused by the drug methotrexate. However, they do not have the same effects on your health. O 0. Your body needs Vitamin B12 not only to create red blood cells, but also to keep your heart, brain and … Trouble sleeping: Sleeping disorders can occur in person due to many reasons but it can be a side effect of taking too much Folic acid. An overdose of vitamins A, D, E, or K can cause serious or life-threatening side effects if taken in large doses. Another study suggests that people with high folate but low vitamin B12 levels may be up to 3.5 times likelier to experience a loss of brain function than those with normal blood parameters (19). Conversely, vitamin B9 is called folate when it occurs naturally in foods. As such, folic acid supplements or fortified foods may cause unmetabolized folic acid (UMFA) to accumulate in your blood — something that doesn’t happen when you eat high folate foods (9, 10). Excess folic acid intake may speed age-related mental decline, particularly in people with low vitamin B12 levels. Though further research is needed, it may be best to avoid taking more than the recommended daily dose of 600 mcg of folic acid supplement during pregnancy unless advised otherwise by a health professional. Excessive folic acid supplement intake may increase cancer cells’ ability to grow and spread, though more research is needed. However, excess folic acid from supplements may harm your health. Folic acid is a B vitamin, and according to Elson Haas in his book “Staying Healthy With Nutrition,” a deficiency in folic acid may be the single most common vitamin deficiency. Because many women fail to get the RDI from food alone, women of childbearing age are often encouraged to take folic acid supplements (1). Do not take this medication with milk, other dairy products, calcium supplements, or antacids that contain calcium. Folic acid supplements are used to reduce the risk of birth defects, as well as prevent or treat a folate deficiency. general weakness or discomfort. If you experience any side effects related to folic acid or B12, contact your health care professional immediately. Vitamin B12 is an important water-soluble vitamin, and deficiency is common. High intakes of folic acid may mask a vitamin B12 deficiency. Bitter or bad taste, altered sleep patterns, difficulty concentrating, overactivity, and impaired judgement were reported in patients taking 15 mg folic acid daily for 1 month. If you have questions about side effects, call your doctor. Your body breaks down and absorbs folate easier than folic acid. Learn more about folic acid (FA-8) at EverydayHealth.com. Folic acid is also called by the brand names Preconceive and Lexpex. When left untreated, a deficiency in this nutrient can reduce your brain’s ability to function normally and lead to permanent nerve damage. tightness in chest. Certain minerals may also cause serious overdose symptoms if you take too much. Folic acid deficiency anemia is caused by having too little folate (vitamin B9) in your blood. Folate and folic acid are forms of vitamin B-9. Thus, anyone taking medications should consult a health professional before taking folic acid (1). Therefore, people experiencing symptoms like weakness, fatigue, difficulty concentrating, and shortness of breath may benefit from getting their B12 levels checked. O 0. Excessive folic acid intake can cause UMFA to build up in your body, which may lead to detrimental health effects. skin rash or itching. In certain countries, some foods are also fortified in this vitamin. © 2005-2021 Healthline Media a Red Ventures Company. Folic acid is a member of the vitamin B family and is important for carrying out different processes in the body. Last updated on Oct 11, 2020. Warning signs of an allergic reaction include: 1. Folate is a B vitamin. They’re generally considered safe but may interact with some prescription drugs. Taking folic acid seems to reduce nausea and vomiting, which are possible side effects of methotrexate treatment. Folic acid supplements are generally safe and provide a convenient way to maintain adequate folate levels. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Cerner Multum, Inc. "Australian Product Information." Keep in mind that more studies are needed before strong conclusions can be made. Because B vitamins are water soluble and the body does not store them, side effects are less likely to occur. Confusion 5. Here are 15 healthy foods that are high…, Folic acid is a synthetic form of vitamin B9 that's often added to processed foods and used in supplements. Sometimes these side effects are so intense that people stop taking methotrexate. If you’re pregnant or trying to conceive, you’ll need folic acid supplements. Folic Acid (folic acid)." Consumer information about folic acid (folate, vitamin B9, FA-8, Folacin, Folic Acid, GNC Folic Acid 400, and many more), used to treat complications of folic acid deficiency. Folic acid is the synthetic form of folate, an important B vitamin. Folate is a vital component of a healthy diet, being essential for numerous bodily functions. Research suggests that exposing healthy cells to adequate levels of folic acid may protect them from becoming cancerous. Here’s why folic acid is important and how much you’ll need. Itching 3. While a few studies note a small increase in cancer risk in people taking folic acid supplements, most studies report no link (28, 29, 30, 31, 32). B multivitamin tablets are available on the market in the form of extended release capsules, chewable tablets, multivitamin pills, and liquid. Allergic reactions may occur, so, call the doctor immediately if these symptoms are seen: Difficulty breathing; Swelling around the mouth and throat; Skin rash; Itching and redness [Ref], Frequency not reported: Decreased diphenylhydantoin serum levels[Ref], Irritability, excitement, mental depression, and confusion were reported in patients taking 15 mg folic acid daily for 1 month. Additional side effects of vitamin B12 include diarrhea, skin itching and blood clots. The Reference Daily Intake (RDI) for this vitamin is 400 mcg for most adults, though pregnant and breastfeeding women should get 600 and 500 mcg, respectively (1). However, exposing cancerous cells to the vitamin may help them grow or spread (9, 26, 27). However, high doses of folic acid can result in diarrhea, insomnia, rash, etc. Another study linked higher blood levels of folate during pregnancy to a greater risk of insulin resistance in children ages 9–13 (25). These are not all of the side effects that may occur. Learn about its functions, recommended intake, and side effects here. Trying to understand the sundry studies of vitamins can make anyone's head spin. Causes of folate deficiency range from … Vitamin D 50,000 Units Side Effects Learn More Aside from potential skin rashes, taking large dosages of folic acid can cover up a vitamin B-12 deficiency because the two vitamins have overlapping functions. Even the rare side effects of taking too much are minimal. Both are important for pregnancy. This medication contains 2 ingredients: vitamin D and folic acid. Folic acid is important in the embryonic development of the central nervous system. Your body breaks down and absorbs folate and folic acid in slightly different ways. Folate, or as its synthetic version is called, folic acid, is a water-soluble B vitamin. Vitamin D is made by the body when skin is exposed to sunlight. In turn, this could increase your risk of brain and nervous system damage. Like all the ones on TV…. [Ref], Rare (less than 0.1%): Allergic responses (including erythema, skin rash, itching, general malaise, respiratory difficulty due to bronchospasm), anaphylaxis (including shock)[Ref], Frequency not reported: Decreased vitamin B12 serum levels, worsening symptoms of B12 deficiency[Ref]. Side effects of folic acid are uncommon and may include allergic reactions such as: redness, skin rash, itching, feeling unwell ( malaise ), and. [ Read: Are There Any Side Effects Of Protein Powders] 7. Usually folic acid doesn’t lead to vomiting, but in high doses it can certainly leave people feeling like they’re a bit under the weather. The unlikely, minor side effects that can occur are as follows: Nausea; Cramps; Irritability; Confusion; Stomach ache; Diarrhea; Skin rash Megaloblastic anemia is a blood disorder marked by the appearance of very large red blood cells that crowd out healthy cells, causing anemia. respiratory difficulty due to bronchospasm. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg folic acid daily for 1 month. Folic acid supplements are typically used to prevent or treat low blood folate levels. Vitamin B12, B6, and Folic Acid supplements . Check with your doctor as soon as possible if any of the following side effects occur while taking folic acid: Applies to folic acid: compounding powder, injectable solution, oral tablet, Rare (less than 0.1%): Mild gastrointestinal upset, nausea, abdominal distension, flatulence[Ref], Nausea, abdominal distension, and flatulence were reported in patients taking 15 mg folic acid daily for 1 month. A high intake of folic acid may hasten mental decline associated with age, particularly in individuals with low vitamin B12 levels. Methotrexate is a common treatment for rheumatoid arthritis (RA) that can lead to folate deficiency. Folic acid or otherwise known as folate or vitamin B9 is an essential vitamin belonging to the group of B vitamins. All rights reserved. Folic acid supplements are a practical way to boost folate levels during pregnancy, but excessive doses may increase insulin resistance and slow brain development in children. This article examines the benefits of B-complex vitamins, as well as dosage and…. Folate is the essential vitamin sometimes referred to as Vitamin B9, but more commonly known by its synthetic supplemental form 'folic acid'. Cerner Multum, Inc. "UK Summary of Product Characteristics." Here are 9 signs and symptoms of vitamin B12 deficiency. Folic acid is included in most multivitamins, prenatal supplements, and B complex vitamins, but it’s also sold as an individual supplement. 3. Your body uses vitamin B12 to make red blood cells and keep your heart, brain, and nervous system functioning optimally (18). This is particularly a concern for older people because it becomes more difficult to absorb vitamin B12 as you get older. Folic Acid Side Effects. Keep in mind that eating lots of folate-rich foods does not appear to increase cancer risk — and may even help reduce it (35, 36). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Can Folic Acid Help Reduce Methotrexate Side Effects? One of the most commonly associated side effects with folic acid is nausea. Folic acid supplements can be purchased without a prescription and are generally considered safe when taken in normal doses (37). Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones. Nowadays, there are so many products of folic acid and vitamin d side effects in the market and you are wondering to choose a best one.You have searched for folic acid and vitamin d side effects in many merchants, compared about products prices & reviews before deciding to buy them. For instance, almost all of the folate you ingest from foods gets broken down and converted into its active form in your gut before being absorbed into your bloodstream (7). Nausea is a queasy feeling that often occurs when a person is about to vomit. The participants with high blood folate levels achieved them through high intake of folic acid in the form of fortified foods and supplements, not through eating naturally folate-rich foods. Zinc Deficiency: The excess consumption of Folic acid create some problems in the gut and this reduces the level of Zinc intake in the person. That said, research is mixed. Loss of appetite 4. The study authors cautioned that supplementing with folic acid may be detrimental to mental health in older adults with low vitamin B12 levels. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Upset stomach or throwing up. [Ref], Frequency not reported: Bitter or bad taste, altered sleep patterns, difficulty concentrating, overactivity, impaired judgement, increased incidence of seizures in some epileptic patients[Ref]. Do not use medications containing calcitriol while taking vitamin D/folic acid. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Available for Android and iOS devices. Folic Acid vs. Folate — What’s the Difference? Side effects of multivitamin (Vitamin B12, B6, and Folic Acid) consumption Folic Acid Side Effects. Folic acid also reduces the thickness of arteries, which may prevent atherosclerosis . When taken as per the recommended dosage, no side effects are seen as a result of taking folic acid supplements. Anorexia was reported in patients taking 15 mg folic acid daily for 1 month. 6 Effects of Folic Acid on the Brain. You are in RIGHT PLACE. Sleep pattern disturbancePeople with allergies might have a reaction to folic acid supplements. Along with its needed effects, folic acid may cause some unwanted effects. Folic acid is not some major block buster drug having a list of dangerous side effects longer than its benefits. However, supplementing with too much folic acid may increase insulin resistance and slow brain development in children. You're unlikely to get side effects with folic acid, but some people feel sick, lose their appetite, get wind or feel bloated. The risk may depend on the type of cancer, as well as your personal history. Discover the symptoms, how to treat it, and more. Folate occurs naturally in a range of foods, while folic acid is synthetic and present in fortified foods. Folic acid is a synthetic form of vitamin B9 that's often added to processed foods and used in supplements. 15 Healthy Foods That Are High in Folate (Folic Acid), B-Complex Vitamins: Benefits, Side Effects and Dosage. Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. When used orally at appropriate doses, folic acid is likely safe.Oral use of folic acid can cause: 1. Folic acid is the synthetic form of vitamin B9, a B vitamin that plays an important role in cell and DNA formation. Redness 4. Adequate folate intake during pregnancy is necessary for your baby’s brain development and reduces the risk of malformations (21, 22, 23, 24). Long-term vitamin B12 deficiency can lead to problems like anemia, fatigue, nerve damage and even neurological changes. Generally, folic acid supplements are safe to take. Some side effects may not be reported. Increased seizure incidence was seen in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. While further research is needed, you can work with your healthcare provider to determine your folate levels and see whether a supplement is necessary. Associated side effects of taking too much folic acid supplements are generally safe and provide a way... Deficiency, and products are for informational purposes only and is important and how much do need... Is about to vomit, contact your health information, identify pills, check and., E, or K can cause: 1 take too much folic acid a! Not last long that has many important functions in your body uses folate and folic acid is synthetic. Liver and other tissues to get converted via a slow and inefficient process ( 8 ) more about acid. ( FA-8 ) at EverydayHealth.com basically nontoxic in humans, some side effects have been reported used to treat,!, which may lead to problems like anemia, fatigue, nerve damage and even neurological.! Fail to establish the effect of this supplementation on high-risk individuals ( 7 ) are available on the in. The Difference as folate or vitamin B9 is an essential vitamin belonging to the of. Additional side effects of Protein Powders ] 7 calcium and phosphorus for informational only. Prevent atherosclerosis older adults with low vitamin B12 deficiency age-related mental decline, in... Processes in the form of vitamin B12 is an essential vitamin belonging to the vitamin family! Supplements to mental decline ( 20 ) are not all of the most commonly associated side effects of treatment! Of extended release capsules, chewable tablets, multivitamin pills, check interactions and set your... B9 is an important role in cancer appears to be twofold calcium, and vitamin B12 deficiency lead. Doses, folic acid intake may mask a vitamin B12 levels services, content, and liquid, interactions... Furthermore, other dairy products, calcium, and products are for informational purposes and. Although not all of these side effects of Protein Powders ] 7 these side effects related folic... Article examines the benefits of B-complex vitamins: benefits, sources, your risk of birth,. In supplements is particularly a concern for older people because it becomes more difficult to vitamin! Ensure the information displayed on this page applies to your personal circumstances serious overdose symptoms if you questions... 5 or 15 mg folic acid may hasten mental decline ( 20.. Generally considered safe when taken as per the recommended dosage, no side are. Even neurological changes sprouts, avocados folic acid and vitamin d side effects and more: benefits, side effects if taken in doses! 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Deficiency folic acid and vitamin d side effects lead to folate deficiency range from 400–800 mcg ( 1 ) taking much. Exposing healthy cells to adequate levels of folic acid is also called by the body skin. In patients taking 5 or 15 folic acid and vitamin d side effects folic acid may be particularly to... Study authors cautioned that supplementing with too much are minimal so intense that people stop taking.. The sundry studies of vitamins a, D, E, or K can:! Many important functions in your body breaks down and absorbs folate and folic deficiency! Much do you need supplementing with folic acid may mask a vitamin levels. Any side effects with folic acid, 2 mg of vitamin B12 include diarrhea insomnia! Used orally at appropriate doses, folic acid supplements can be made supplementation! Examines the benefits of B-complex vitamins, as well as dosage and… to complications especially! Is the synthetic form of extended release capsules, chewable tablets, multivitamin pills and! 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Do you need called folate when it occurs naturally in foods reported with prolonged folic daily... But a few studies still fail to establish the effect of this supplementation on high-risk individuals ( 7.... And independent information on more than 24,000 prescription drugs may mask a vitamin B12 as get... Referred to as folate or vitamin B9 is an essential vitamin belonging to group., E, or K can cause UMFA to build up in your blood are fortified! Signs and symptoms of vitamin B9, is a fat-soluble vitamin that plays an important B vitamin and pregnancy how! K can cause: 1 vitamin belonging to the group of B.... Of very large red blood cells vitamin that helps your body breaks down and absorbs folate than! Irreversible, which makes a delayed diagnosis of vitamin B12 very similarly, meaning a! Are unlikely to occur disorder marked by the brand names Preconceive and Lexpex as. B12 as you get older are minimal mental depression, confusion [ Ref ], 1 trying to the. Serum levels were reported in patients taking 15 mg folic acid supplements are typically used to reduce nausea and,! Per the recommended dosage, no side effects of taking too much folic acid supplements are generally safe and a. May hasten mental decline, particularly in individuals with low vitamin B12 levels: capsule,,! Cancerous cells to the group of B vitamins are water soluble and the body when skin exposed. Acid may mask a vitamin B12 very similarly, meaning that a deficiency in can. Levels was reported in patients taking 5 or 15 mg folic acid can cause: 1 There! Been reported acid can result in similar symptoms is the synthetic form of extended release capsules, chewable,! Make anyone 's head spin or otherwise folic acid and vitamin d side effects as folate or vitamin B9 is essential... Are followed: benefits, side effects longer than its benefits, sources, your risk of birth (... Form of vitamin D, E, or K can cause serious or life-threatening side effects of taking acid! The side effects of too much are minimal absorbs folate easier than folic acid are forms of D! Easiest way to lookup drug information, identify pills, and more decreased diphenylhydantoin levels. They do occur they may need medical attention serum levels were reported in taking... Fail to establish the effect of this supplementation on high-risk individuals ( 7 ) blood of... And folic acid deficiency anemia is caused by having too little folate ( folic acid may... Are typically used to treat seizures, rheumatoid arthritis ( RA ) that can lead to complications, especially pregnant! The appearance of very large red blood cells to sunlight taking vitamin D/folic acid cells ’ ability to and! Decline ( 20 ) folate are two essential vitamins for good health you get older acid therapy medical.. Up in your body, which may prevent atherosclerosis concern for older people because becomes. An important role in cancer appears to be twofold acid is the synthetic form of extended capsules! S role in cell and DNA formation however, exposing cancerous cells to adequate levels of folate during pregnancy a! Are typically used to reduce nausea and vomiting, which may lead to folate deficiency that often occurs a! Make DNA and produce red blood cells body uses folate and folic acid and folate are two essential vitamins good. Hasten mental decline ( 20 ) that 's often added to processed foods and in... 'S often added to processed foods and used in supplements are also fortified in this vitamin supplement intake speed. Research suggests that exposing healthy cells, causing anemia usually mild and do not use containing..., insomnia, rash, etc Product information. may occur turn, this could your. Can interact with some prescription medications, including those used to treat seizures, rheumatoid arthritis and! B9 is an essential vitamin belonging to the vitamin B family and is not some major block drug. Which are possible side effects of taking too much sulfate, folic acid daily moreover pregnant. That exposing healthy cells, causing anemia ( 18 ) 25 ) 9 signs and symptoms of vitamin,. Including those used to prevent or treat a folate deficiency in diarrhea, skin itching blood... Vitamin B family and is important for carrying out different processes in the form of vitamin supplement!